Essential engineering works will see buses replace trains between Kilwinning and Paisley Gilmour Street this Saturday.
Journey times will be extended and the route is expected to be busy as fans travel to see the rugby clash between Scotland and Wales at Murrayfield.
A spokesperson for ScotRail said: "If you're going to Murrayfield, please allow extra time for travel, and buy your ticket in advance, not on the day.
"The last trains of the night will be very busy, so please aim for an earlier service."
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