Hunterson Road (B7048 Portencross Road to Main Street) is undergoing carriageway resurfacing works. Motorists are asked to follow the diversion.
A Stagecoach spokesperson said: "Due to roadworks, West Kilbride Main Street cannot be served going to Greenock."
The West Kilbride works are only for today.
There are currently roadworks in Glen Road in Fairlie and traffic controls in place at the junction on the A78.
The Fairlie works are from 8am till 5pm until 23 August.
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